Question: Secretions can also be controlled by
medications. Before we review these, can you think of any down sides to
drying the secretions?
Answer: Systemic drying agents will dry
all secretions, including respiratory secretions. This
can make chest clearance a lot more difficult. Anticholinergic agents
such as hyoscine or glycopyrrolate
should be used carefully.
Sometimes it is better to use targeted local therapy.
Atropine is another anticholinergic but in the 1% eye
drop form, can be administered topically into the buccal mucosa or sub
lingually (under the tongue). This can have a local effect on secretions,
and although there is some systemic absorption, this isn’t
significant.
Amitriptyline is a tricyclic antidepressant but has
anticholinergic side effects – most notably a dry mouth.
A more targeted approach involves the use of Botulinum
toxin, exerting its effect through the blocking of acetylcholine
(Ach) release at the neuromuscular /neuroglandular junction. Different
sub-types vary in exact mechanism of action. Small doses of Bo-tox are
injected into the salivary glands under ultrasound control. This is a
specialist procedure but is effective in controlling saliva
production.
There are detailed resources in the downloads section.
Select the Question -
effectiveness tab to continue.